Brenae Ashton
Brenae Ashton


Recommend0 recommendationsPublished in College of Pharmacy, Virtual Poster Session Spring 2021


  1. Nice colors! In the first study were you able to calculate number needed to treat? In the second study how does the dose used compare to that in the first study. What do you think of the study design in the second study? How do doses in the studies compare to what is stated in Natural Medicines? Would you recommend its use?

    1. According to the Natural Medicines website, most commercial products containing passion flower contain 250-900 mg per dose. The first study evaluated patients initially taking 2 capsules of 200 mg twice daily, for a total of 800 mg per day to treat generalized anxiety. The second study used passion flower in the dosage form of drops instead of capsules, making it difficult to compare the 2 studies in terms of dosing. According to the manufacturer’s website of the drops used in the study, 100 mL of the drops contains 11-15 mg of active ingredient. The patients in the second study were required to take 20 drops the night prior to and morning of dental treatment to reduce anxiety.
      As far as study design for the second study goes, I found it very effective to have both a placebo and a negative control group. Comparing the results on the graph provided on the poster showed that there was not much of a “placebo effect” in group 2, and that passion flower proved to be the most effective out of all options from the study. It would be interesting to see how it compared to pharmaceutical anxiolytics.
      For recommending the product, I do not see too much harm in this product, with the common side effects being mild sedation, dizziness, and hypersensitivity. However, I would encourage patients to look into other options in order to effectively treat their anxiety since there is much more research that needs to be done.

    2. Hi Dr. Shane-McWhorter! Unfortunately, I was unable to access the supplementary index in the first study to obtain the actual number of patients that were considered to be in remission at visit 2 (the study only reported a percentage of patients) and with a lack of placebo/control group, it was difficult to calculate a NNT. With that being said, I would have a hard time solely recommending the use of passion flower based on this study due to its limitations.

  2. Very interesting topic and awesome job on the poster! Do you think that passion flower could potentially have superiority over traditional anxiolytics? If so, in what ways?

    1. Hey Gisoo! I think that the few studies we found show promising results when it comes to using passion flower as an anxiolytic. One benefit of using this natural product could be that we reduce the amount of benzodiazepines that are prescribed which also replace some side effects that go along with taking benzos like less sedation and memory loss. Decreasing the use of a controlled substance and replacing it with what could be a non-addictive treatment would also be a win. With that being said, studies on passion flower lack critical data like large human studies and studies that include a placebo or control group. In order for passion flower to even be considered clinically we would have to make large strides to prove the superiority over traditional anxiolytics.

  3. Very interesting! I am curious though, is there any specific types of anxiety that passion flower is used for?

    1. The majority of the studies that have been done address mild to moderate non-specific anxiety. I did look into generalized anxiety but there were very few studies and most of them only used animal subjects.

  4. I like the color in your poster! I have never heard of this product before. I found it interesting that is was named by Spanish missionaries in the 15th century. Where did you get the idea for this poster?

    1. Hey Jared! We knew that we wanted to look at anxiety as the topic for our poster so with a quick google search we found that this has been a topic of discussion by multiple people and we were able to find a few studies to further base our poster off of.

    2. Hi Jared, it is also the blossom for the passion fruit, which is something I see everyday in the supermarket, and thought it would be interesting!

  5. Your poster looks great! I noticed your dosing said to use passion flower along with sertraline. Did you find studies that compared sertraline alone with sertraline and passion flower?

    1. Hi Jennie, I found this article by Mandana Nojoumi et al. at Iran J Psychiatry from 2016 who performed a double-blind placebo controlled study looking at passion flower as an add on to sertraline vs sertaline alone. The conclusion from this study was that passion flower could be a useful add on, but more studies would need to be done to confirm this. I also did a google search and was able to find similar articles with similar results as to the one my Mandana Nojoumi.

  6. Hi Brenae, Jaqueline and Cassandra!
    Interesting topic involving the Passion Flower! I was not aware of all the background info you provided on this flower, all the way back to biblical times. Regarding Study 2, did the authors use any type of measurable anxiety tool? (Study 1 used the HAM which was good to see.) Also, what is the labeling of the x and y axis in Study 2 graph? Poster is well organized and balanced. Thank you for sharing your expertise on this topic!

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